CALGB 80101

Description of the trial: The purpose of this study is to determine which of the following combinations of chemotherapy and radiation are more effective in preventing the return of stomach cancer:

• 5-FU and leucovorin in combination with radiation therapy, or:
• epirubicin, cisplatin, and 5-FU in combination with radiation therapy

This study will find out what effects (good and bad) the combination of epirubicin, cisplatin and 5-FU plus 5-FU with radiation therapy to the abdomen will have in the treatment of stomach cancer.

Population: Patients with adenocarcinoma of the stomach or gastroesophageal junction that have undergone a surgical resection. Patients that have had previous chemotherapy or radiation therapy are not eligible.

Principal Investigator: Peter Tate, M.D.

Contact: For more information about the trial call Teresa Roberts, RN, Clinical Coordinator, at (859) 260-6362 or e-mail troberts@bhsi.com.